The Barclays Under-21 Premier League – originally planned for a day later – will be staged at St Mary’s with a 2pm kick-off.
Southampton’s welcoming of the Magpies represents their last clash of the group stage, with Martin Hunter’s third-placed team battling to retain a top-four position to ensure entry to the final stage of the competition.
Saints will be familiar with Newcastle’s side, having secured a 2-0 victory over them in their 2013/14 pre-season tour of the north east.
Tickets will be available to attend the match at the Club’s stadium, with an announcement coming on saintsfc.co.uk
in the near future.