A limited number of tickets still remain for the game against the Magpies, which takes place on Saturday 9th April, with a 3pm BST kick-off time.
Ronald Koeman's men drew 2-2 with Newcastle, who are now managed by Spaniard Rafa Benítez, in their opening fixture of the 2015/16 campaign.
Saints, following the memorable 3-2 win against Liverpool on Sunday, are now pushing for a second consecutive top seven finish in the Premier League.
Newcastle meanwhile currently sit in the relegation zone, following a 1-1 draw with Sunderland at the weekend.
With just three home games remaining in 2015/16, make sure you're at St Mary's for the game against the Magpies.