The Saints forward has linked up with his country for the Group K double-header, with the first game in Dakar on Saturday, before the sides face each other in Niamey next Tuesday.
Senegal currently top the standings, having taken maximum points from their opening two matches, and will be looking to reinforce their position, with only the first-placed side guaranteed a place in next year’s finals.
"For the international break we have important games, because it's AFCON qualification,” Mané told Southampton’s official YouTube channel
. “Our ambition is to qualify, but we have to win all our games. We're going to do our best to win games and to qualify for our country.
"We start at home, so we're going to try to do our best like always, to give our best for the fans, the country and to make them happy.
"It does mean a lot for the country. They try to help us every day and every time, so I think we also have to give back to them by winning games.”