The gaffer made eleven changes to his team for the trip to Elland Road, resting those who started against Spurs barely 48 hours earlier.
But their replacements struggled to make an impact against their Championship opponents, ending up on the wrong end of a 3-0 scoreline.
"It was a poor result for us," Adkins told Saints Player
after the match.
"The mindset before the game was to be very positive. Tadanari Lee, Emmanuel Mayuka and Steve De Ridder are blessed with an outstanding amount of pace so the objective was to get on the front foot by utilising that and getting in behind.
"It was a very attacking formation on paper, but on the pitch you have got to go and produce it.
"You're playing for Southampton Football Club, so every game matters. We've got supporters who have travelled, and we've put a team out that I expected to win this game.
"I expect the players to go and perform, so there's obviously going to be consequences of the result and performance for many people.
"We've come out to win a game of football – on paper and in theory that was possible, but we haven't produced.
"I have to take full responsibility for the team that goes out and all it's done," continued the manager.
"I've made changes because we played 48 hours ago, and you can talk about the recovery process all day long – the last thing you want to do is lose players for long periods of time.
"We've got to make sure that we address anything that is going wrong in any way we can for the sake of this football club, because that's what it's about."
A full interview with Nigel Adkins will be on Saints Player shortly