Nathaniel Clyne and Gastón Ramírez were forced to withdraw from the England Under-21 and Uruguay squads respectively due to the injuries they suffered in the lead up to Saints' game against Fulham last weekend.
But Danny Fox, Maya Yoshida, Emmanuel Mayuka, Steven Davis and Alberto Seidi are all set to be involved having travelled to link up with their compatriots earlier this week.
Here's a run down of the games in which Saints players will hope to feature:
Friday 12th October, 7.45pm kick-off BST
DANNY FOX: Wales v Scotland – FIFA 2014 World Cup European Qualifying Group A, Cardiff City Stadium (Cardiff, Wales)
Friday 12th October, 8pm kick-off BST
MAYA YOSHIDA: France vs Japan – Friendly, Stade de France (Saint Denis, France)
Saturday 13th October, 2pm kick-off BST
EMMANUEL MAYUKA: Uganda vs Zambia – 2013 Africa Cup of Nations Second Round Qualifier Second Leg, National Stadium (Kampala, Uganda)
Monday 15th October, 6pm kick-off BST
ALBERTO SEIDI: Portugal U21 vs Ukraine U21 – Friendly, Parque de Jogos Comendador Joaquim de Almeida Freitas (Moreira de Cónegos, Portugal)
Tuesday 16th October, 1.10pm kick-off BST
MAYA YOSHIDA: Japan vs Brazil – Friendly, Stadion Miejski (Wrocław, Poland)
Tuesday 16th October, 7.45pm kick-off BST
DANNY FOX: Belgium vs Scotland – FIFA 2014 World Cup European Qualifying Group A, Koning Boudewijnstadion (Brussels, Belgium)
Tuesday 16th October, 8.45pm kick-off BST
STEVEN DAVIS: Portugal vs Northern Ireland – FIFA 2014 World Cup European Qualifying Group F, Estádio do Dragão (Porto, Portugal)
Furthermore, as revealed yesterday, Luke Shaw will be involved with England's Under-18s when they face Italy in a friendly on Wednesday 24th October.