This is our first trip to Loftus Road in four seasons with our previous meeting there played out in the Championship which ended 4-1 to the hosts, with current Saint Adam Lallana netting for the visitors on that day.
Current Saints stars Jack Cork, Morgan Schneiderlin, and Kelvin Davis are the other players who were involved in that game.
This time around the stakes are arguably higher with both teams keen to kick-start their campaigns. Rangers are yet to win a league game this season and sit bottom of the table, whilst Saints are hoping to end a run of five league defeats on the road the latest of which came at West Bromwich Albion almost a fortnight ago.
Buoyed by last weekend’s spirited performance against Swansea City at St Mary’s, Nigel Adkins confirmed in his Thursday afternoon press conference that both Richard Chaplow and Frazer Richardson are the only expected absentees from the squad.
Six players who were in the squad against the Swans - James Ward-Prowse, Nathaniel Clyne, Steven Davis, Maya Yoshida, Gastón Ramírez and Emmanuel Mayuka have all returned from midweek international duty.
Opponents QPR have a few worries ahead of the game. Definitely out is defensive midfielder Stephane Mbia who is suspended, whilst full back Fabio and forward Andrew Johnson have long term injuries.
There are doubts over the fitness of Ryan Nelsen and Park Ji-Sung, whilst Kieron Dyer hasn’t featured for them since the end of September.
The links between the two teams include Jason Puncheon, who had a brief loan spell at Loftus Road last season, whilst R’s midfielder Shaun Derry is an old Crystal Palace teammate of Jose Fonte, Danny Butterfield and Nathaniel Clyne.
Our last meeting with Rangers came in March 2009 at St Mary's, where a dour 0-0 draw did little to ease the hosts’ relegation fears, whilst the stalemate also proved to be the beginning of the end for Paulo Sousa’s reign of QPR with the Portuguese boss leaving his post a month later.
As previously mentioned, earlier that season Saints were undone in a 4-1 defeat at Loftus Road, although the visitors played much of that game with ten men after Olly Lancashire had been sent off after half an hour. Adam Lallana’s marvellous finish from a well worked team goal was later voted as the club’s goal of the season.
Loftus Road has generally been a decent hunting ground for Saints though with the previous season’s meeting there resulting in a 3-0 win on 1st September 2007 which was secured by a brace of goals from Grzegorz Rasiak and a Bradlkey Wright-Phillips header just after half time.
Overall the two teams have played one-another on 73 occasions in league and cup. 26 of those have gone the way of QPR, 26 have resulted in Saints wins and 21 in draws.
All tickets for the game are now sold
. Please do not travel without a ticket.
Mike Dean will referee Saturday’s game, and he will be assisted by Mr J Collin and Mr J Brooks. Lee Mason is the fourth official.
If you plan to drive into West London tomorrow, head out of Southampton via the M3, and join the M4 via the M25. Leave the M4 at junction 2 merging on to the A4 and A406 before finding the A4000 heading towards Shepherds Bush. Follow signs to White City (Wood Lane) and turn left into South Africa Road.
It is street parking only in the surrounding area. Please note that it is a residential parking area and it is advisable to read the signs before parking.
The nearest tube station is White City on the Central Line, which is about a five-minute walk away.
Also nearby (a little further along Wood Lane opposite the BBC Television Centre) is Wood Lane Station, which is on the Hammersmith & City line. It is approximately a seven-minute walk to Loftus Road.
Alternatively, there are two other tube stations close by. Shepherd's Bush Market on the Hammersmith & City line and Shepherd's Bush on the Central Line.
The nearest overground train station is Shepherd's Bush, which is adjacent to the tube station. Trains from Watford Junction and Clapham Junction both stop here.
As with every First Team game, we'll be providing minute-by-minute coverage throughout the day on our official Twitter
feed plus goal updates on our official Facebook
You can listen to live commentary courtesy of BBC Solent on Saints Player
, where you can keep up to date with all the stats and scores from around the country.
Nigel Adkins and Rickie Lambert spoke to Saints Player ahead of the game, and you can watch their interviews – as well as the gaffer's full press conference – now.
Fans travelling to West London are asked to contribute to our next official matchday programme by sending in their pictures via Twitter
and Instagram – just add the hashtag #MarchingIn.