Artur Boruc returns to the team in goal, with Kelvin Davis dropping to the substitutes' bench. Jay Rodriguez is replaced by Gastón Ramírez.
Jack Cork moves to right-back and Maya Yoshida returns to centre-half, so Steven Davis comes into midfield with Jos Hooiveld among the substitutes.
Southampton youth products Theo Walcott and Alex Chamberlain start for the Gunners.
Saints team: Boruc, Cork, Fonte (c), Yoshida, Shaw, Puncheon, Schneiderlin, S. Davis, Guly, Ramírez, Lambert.
Substitutes: K. Davis (GK), Hooiveld, Rodriguez, Ward-Prowse, Richardson, Mayuka, De Ridder.
Arsenal team: Szczesny, Sagna, Vermaelen (c), Koscielny, Gibbs, Arteta, Wilshere, Chamberlain, Cazorla, Podolski, Walcott.
Substitutes: Martinez (GK), Mertesacker, Coquelin, Ramsey, Rosicky, Gervinho, Giroud.
Referee: L Probert
Assistant Referee: R Ganfield & M Wilkes
Fourth Official: M Jones
Click here to view a PDF version of today's official teamsheet