With a place in the last 16 of the competition up for grabs, Southampton take on one of the lowest-ranked sides left in the tournament, keen to make the most of the home advantage offered to them.
The tie is a reward for coming through the second-round trip to Barnsley last month. Saints recorded a 5-1 success at Oakwell with Steven Davis and Jay Rodriguez amongst the goalscorers on the night.
Bristol City have come through two matches to get this far – Sean O’Drsicoll’s side beat Gillingham in round one, before going on to knock top-flight Crystal Palace out of the competition three weeks later.
In the last round, the Robins were the only team to beat a Premier League side and, intriguingly, City have saved their best form for the cups this season, as they also beat neighbours Bristol Rovers in the Johnstone’s Paint Trophy.
Following Saturday’s 3-2 defeat to Swindon Town, they remain without a league victory this season and currently reside 21st in League 1.
Saints, meanwhile, are still searching for their first home win of the season and, with back-to-back league games at St Mary’s fast approaching, will want to take the earliest possible opportunity to break their duck on home soil.
Mauricio Pochettino may take the opportunity to rotate his squad again, with a number of younger players hoping to get the chance to impress once more.
The likes of Harrison Reed, Jake Sinclair and Omar Rowe all made their debuts in the last round, whilst the game could also be a chance for other players who haven’t featured much in the league this term.
Danny Fox, Guly do Prado and Tadanari Lee were absent from Saturday’s win at Liverpool but could all come back into contention on Tuesday.
City will be without defender James O’Connor, who is injured, whilst there are doubts over Louis Carey, Aden Flint and Marvin Elliott.
Striker Marlon Harewood and goalkeeper Elliot Parish have been regulars in the cup teams for the Robins so far this season, and are expected to play some part again on Tuesday.
The Robins have become something of a bogey team for Saints in recent meetings, winning five of the last six matches, including the last two at St Mary’s.
City ended Saints’ unbeaten calendar year run in 2011 with a 1-0 victory in the previous fixture here. Midfielder Stephen Pearson grabbed the decisive goal of the game as the visitors recorded their fifteenth all-time win over Southampton.
Saints’ last win over the Robins came in April 2008 when Stern John and Jason Euell struck in either half to record a 2-0 victory.
The two teams have met only once in League Cup competition, with Saints 3-0 winners at Ashton Gate in October 2003 thanks to goals from James Beattie, Brett Ormerod and Graeme Le Saux.
Overall, there have been 37 meetings between the two teams, with Saints winning 16 of those matches to City’s 15, and six games ending in a draw.
Graham Scott will referee Tuesday’s game, and he will be assisted by Mr D Blunden and Mr D Robathan. Gavin Ward is the fourth official.
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