Artur Boruc, Steven Davis, Vegard Forren, Gastón Ramírez, Calum Chambers, James Ward-Prowse and Lloyd Isgrove will all join up with their national squads this weekend.
Boruc is back in the Poland squad after a two-year hiatus, and will look to win his 47th cap when they face the Republic of Ireland at Dublin's Aviva Stadium on Wednesday 6th February with a 7.45pm GMT kick-off time.
Northern Ireland captain Davis is in Michael O'Neill's squad for a friendly against Malta at the Ta' Qali National Stadium on the same date, with the match kicking off at 7.30pm local time.
Recent signing Forren is in the Norway squad for their friendly against Ukraine, which will be staged at the Estadio Ramón Sánchez Pizjuán in Seville. Kick off is at 6.10pm local time on 6th February.
Ramírez will travel to Qatar for Uruguay's friendly against world champions Spain, which takes place at the Khalifa International Stadium in Doha from 9pm local time next Wednesday.
Ward-Prowse and Chambers are in the England Under-19 squad for their friendly against Denmark, which takes place at the Keepmoat Stadium in Doncaster on Tuesday 5th February with a 7.30pm kick-off time.
Another Saints youngster, Jack Stephens, is currently on stand-by to be called into Noel Blake's 18-man party for that game if required.
has been called into the Wales Under-21 squad for the first time having been selected for their friendly against Iceland at Stebonheath Park in Llanelli on Wednesday 6th February for a 3pm kick-off.
The seven players will link up with their countries after this Saturday's First Team and Under-21 fixtures. They will then return to Southampton in the latter half of next week ahead of the following weekend's matches.
Young striker Ryan Seager
has already been called into the England Under-17 squad
for their Algarve Tournament games against Portugal, Germany and the Netherlands.