The game was originally slated for Saturday 23rd February but has been moved back by a day because of the Magpies' involvement in the Europa League.
Newcastle travel to Ukraine to face Metalist Kharkiv on Thursday 21st February in the second leg of their last-32 tie.
This will be Saints' first visit to St James' Park since February 2006, when we were beaten narrowly in the fifth round of the FA Cup.
Ticketing details for our trip to the north-east will be announced in due course.