As they did last year, the Development Squad will begin their campaign with a trip to the Silverlake Arena to take on Wessex League Premier Division outfit Sholing.
Saints – who won 2-1 at the Silverlake Arena last summer – will face the Boatmen on Tuesday 9th July with a 7.30pm kick-off time.
Then, at 7.30pm on Friday 26th July, Martin Hunter's team will face Conference South side Eastleigh at the Silverlake Stadium.
The youngsters will be treading familiar ground that night, having played four of their Barclays U21 Premier League home games there last season.
The 21s will extend their pre-season preparations into August with a midday kick-off against Brighton & Hove Albion on Saturday 3rd. This match will be played at Sussex FA County Headquarters.
Ticketing details for these matches will be confirmed in due course on saintsfc.co.uk
and via social media.